THE INTERMEDIATE RÔLE OF CARBAMYL-l-GLUTAMIC ACID IN CITRULLINE SYNTHESIS

The intermediate role of carbamyl-L-glutamic acid in citrulline synthesis.

Metabolic functions of biotin. IV. The rôle of carbamyl-l-glutamic acid in the synthesis of citrulline by normal and biotin-deficient rats.

A characteristic consequence of a biotin deficiency in animals is a decreased ability to fix C402 into various tissue components including the amino acid arginine (1). Carbon dioxide is incorporated into arginine as a result of the conversion of ornithine to citrulline in the Krebs-Henseleit urea cycle (2). The methods developed by Cohen and Hayano (3, 4) for the synthesis of citrulline from or...

The catalytic rôle of carbamyl glutamate in citrulline biosynthesis.

CC was shown to be necessary for the reaction with a partially purified system (l), confirming previous data obtained with cruder preparations (2, 3).’ However, the mechanism of this reaction was not clear, since CG did not disappear during the biosynthesis of citrulline (1). Some insight into the mechanism of the reaction was obtained from kinetic data (l), indicating an “activation” of CG in ...

Metabolic Functions of Biotin Iv. the Role of Carbamyl-l-glutamic Acid in the Synthesis of Citrulline by Normal and Biotin-deficient Rats* by Gladys Feldott

A characteristic consequence of a biotin deficiency in animals is a decreased ability to fix C402 into various tissue components including the amino acid arginine (1). Carbon dioxide is incorporated into arginine as a result of the conversion of ornithine to citrulline in the Krebs-Henseleit urea cycle (2). The methods developed by Cohen and Hayano (3, 4) for the synthesis of citrulline from or...

Glutamic Acid-l-semialdehyde, a Hypothetical Intermediate in the Biosynthesis of 5-Aminolevulinic Acid

W hether glutamate-l-sem ialdehyde (G -l-SA ) or 4,5 dioxovalerate (DOVA) is the intermedi­ ate between glutamate and A LA in the C-5 tetrapyrrol pathway is still a matter of controversy. Since no data characterizing G -l-SA are available it is not possible either to identify G -l-SA as intermediate or a precursor of ALA. Therefore, attem pts were made to establish a chemical synthesis of this ...